tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate stands out in organic synthesis as a specialty chemical built on the dioxane ring structure, functionalized with acetate and tert-butyl groups. Across the chemical industry, this compound emerges as an intermediate for pharmaceuticals and specialty materials, shaped by its memorable 1,3-dioxane core. The molecular formula C14H24O6 gives it distinct characteristics, providing a sizable carbon backbone with multiple oxygen atoms that deliver both solubility and reactivity. The tert-butyl and acetyloxy groups steer the compound’s stability and resistance, while simultaneously feeding key bioactivity and compatibility in broader formulations. The structure, marked by its cis-isomerism at the 4-position, impacts its behavior in stereospecific contexts, especially where the physical form roots itself in either solid flakes, crystalline powder, or even as a semi-solid material, depending on conditions and purification processes.
Many researchers and industrial operators encounter tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate as a white to off-white crystalline solid. The purity and physical state often affect the melting point, hovering between 60 °C and 80 °C, and the density typically centers near 1.1 g/cm³ at room temperature. It blends low volatility with moderate solubility in organic solvents such as dichloromethane, ethyl acetate, and to a limited extent in alcohols. A closer look at its material properties uncovers a reliable shelf life under standard conditions, given proper sealing from atmospheric moisture, which can hydrolyze the ester functions and degrade the compound. The acetate groups bring mild reactivity towards bases and nucleophiles, so storage containers usually require chemical compatibility certification. In practical applications, companies sometimes encounter it in solid flakes, free-flowing powder, or compressed pearls, based on transportation needs and ease of handling. Handling the material as a dry solid allows for safe, accurate weighing and straightforward use as a raw material in multi-step syntheses.
The foundational structure of tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate revolves around a dioxane ring substituted with two dimethyl groups and a tert-butyl ester at the 4-position. The (4R-cis) configuration points to a specific three-dimensional alignment, vital in medicinal chemistry for producing precise chiral molecules. By adding an acetyloxy group on the methyl position, the molecule gains functional versatility vital for downstream derivatizations. Its molecular formula C14H24O6 translates into a molecular weight of around 288.34 g/mol, which influences solubility, diffusion rates, and interaction with other reagents, contributing to optimization in process design. The distinct density marks, combined with a stable crystalline lattice, provide insight into safe material packaging and identification, often documented in laboratory records for traceability.
For international shipment and customs documentation, tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate generally classifies under an HS Code reserved for organic chemical intermediates or acyclic/heterocyclic compounds, typically falling in the broad 2915 or 2932 series. Manufacturers publish detailed specifications, covering assay (usually above 98%), moisture, melting point, and impurity profile. Certified suppliers add full analytical and safety data sheets for regulatory submission, ensuring alignment with industry best practices and Safe Chemical Import and Export regulations. “Raw materials” status means the product finds itself upstream in production chains, where quality and consistency directly affect later-stage outcomes, especially with tightly regulated pharmaceutical and biochemical manufacturing.
Anyone familiar with organics knows that handling chemicals like tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate means paying attention to stability and possible hazards. The compound doesn’t show particularly aggressive profiles such as strong oxidizers or acute toxins, but the acetyloxy and tertiary butyl groups raise mild concern. Skin and eye irritation appear on the safety data sheet, so gloves, goggles, and dust control become standard procedure in technical environments. High-dust situations in powder or flakes can bring respiratory discomfort, pushing teams to use local ventilation and dust management. Accidental spills call for prompt neutralization with inert absorbents, then placement in chemical waste containers for proper disposal under hazardous waste rules. The low volatility reduces acute environmental risk, but strongly acidic or basic conditions can release acetic acid or related residues, which need monitored treatment.
This chemical sits inside the toolkit of pharmaceutical chemists chasing stereospecific synthesis. Each batch opens pathways toward either drug intermediates or secure test compounds, with the dioxane-acetate profile built for targeted modifications. As the market seeks reliable, scalable solutions in specialty synthesis, this molecule’s predictable reactivity strengthens confidence, supporting both reproducible results and intellectual property. These aren’t just cold specs—producers weigh cost, purity, and environmental compliance, and the density and crystalline nature shape everything from shipping options to final product documentation. From direct experience, material handling protocols and close supplier communication solve practical problems, ensuring safety, traceability, and reliable sourcing. Answers to regulatory audits lean on detailed characterization, strong COAs, and clear raw material documentation. A solution-focused approach—consistent training, responsible waste handling, and traceable logistics—anchors safe, sustainable use in both academic and industrial labs.
