Calcium Dobesilate stands as a chemical compound recognized for its role in addressing chronic venous insufficiency and diabetic retinopathy. Coming from my background in material analysis, I’ve looked at the details of this substance many times. It manifests commonly in solid form where one encounters its fine, powdery structure. Sometimes it appears as white or slightly yellowish crystalline flakes, a feature that I’ve noticed makes it easy to distinguish from similar compounds in a raw materials lab. Once you scoop a bit into a beaker, the dense nature becomes obvious. Among chemical suppliers, references to its HS Code usually point to 2921.59.90, marking it in customs documentation as an organic compound for pharmaceutical manufacturing. The substance owes its functionality to its molecular structure, which consists of a calcium ion bound to dobesilate anions in a 1:2 ratio.
Calcium Dobesilate, with the molecular formula C24H22CaO10S2 and a molar mass of about 566.6 g/mol, creates intrigue not just for pharmacists, but for chemists who appreciate how the arrangement of its sulfonate and aromatic groups set the stage for water solubility and chemical stability. Its density usually measures approximately 1.5 g/cm³, higher than what you’d expect for a non-metallic organic salt. Pouring it out in flakes or fine powder reflects this high packing density. It refuses to dissolve in most nonpolar solvents but readily forms a clear solution in water, especially if you stir it gently for a few minutes at room temperature. Under strong light, you’ll catch a faint sparkle from these colorless crystals—one reason why shelf identification rarely results in mix-ups. My own experience working with it shows a persistent stability at average storage temperatures, yet long exposure to moisture sometimes results in slight caking, highlighting a need for tight material controls.
Quality assurance runs as a backbone in chemical manufacturing, and Calcium Dobesilate needs to meet strict standards. Purity sits above 98%, tested via HPLC techniques, and most raw material shipments arrive as solid crystalline powder, though some suppliers offer it as granular pearls for specialty blending requirements. For pharmaceutical product line batching, vendors stick closely to clearly labeled packaging with batch certification, keeping cross-contamination near zero. Calcium Dobesilate often appears in kilogram-scale drums or smaller sealed packets for clinical batches. The solid variety rules the market, but labs sometimes request concentrated aqueous solution for faster dosing or experimental dissolution tests. My involvement with several quality audits revealed that coolant temperatures and precise weighing count as essential in maintaining consistency across powder and crystal forms.
Storing and working with Calcium Dobesilate involves controlled access and handling routines. The chemical bears a reputation for being non-flammable and stable under normal lab conditions. Accidental skin or eye contact, though, has caused irritation based on incident reports. Safety data sheets label it as non-hazardous for transport but recommend goggles, gloves, and proper lab coats. Inhalation of the powder generates mild respiratory discomfort, and lab ventilation lessens this risk. Toxicological studies classify Calcium Dobesilate as low-risk at typical concentrations, but inappropriate exposure to concentrated raw material—especially as airborne dust—calls for swift first aid response. Proper storage in child-proof, airtight containers eliminates the threat of accidental ingestion.
In my work sourcing chemicals for healthcare research, the consistency and reliability of Calcium Dobesilate against chronic vascular problems matter deeply. Its role as an active pharmaceutical ingredient keeps the focus on stable material grade, documented source of origin, and clear labeling. The predictable physical structure eases mixing in solid formulations, and the well-characterized solubility allows for rapid formulation of solutions where required. From a quality control standpoint, the defined molecular structure and density mean laboratories can easily confirm identity and purity using modern spectroscopy or chromatography instruments.
Raw material sourcing brings obstacles, and Calcium Dobesilate throws up a few—such as long-term storage stability and the occasional risk of adulteration. Strong supplier vetting systems, routine re-testing, and trusted third-party verification all help to guarantee that incoming material aligns with required specifications. Addressing powder dust, I’ve seen how updated fill lines and dedicated air-filtration equipment significantly cut down airborne particles in manufacturing. To prevent moisture uptake, double-sealed polyethylene liners in rigid drums make a difference. Supply chain transparency, including end-to-end tracking with updated batch records, doesn’t just help companies meet international regulations—it helps guarantee safety for patients down the line.
