4'-Chloropropiophenone stands out in many chemical discussions thanks to its clear physical identity and role in various production lines. Recognized by its molecular formula C9H9ClO and CAS number 34841-35-5, this compound brings together a propiophenone backbone with a chlorine atom at the para position on the aromatic ring. Chemists see 4'-Chloropropiophenone as a building block in the creation of complex molecules, drawing attention from those working in pharmaceuticals, agrochemical development, and specialty intermediate design. Familiarity with its structure can help professionals decide where this compound fits into their process or research focus.
Looking at a sample of 4'-Chloropropiophenone, the first thing that comes to mind is its appearance. Most batches come as a solid, often with a slightly off-white or pale yellow color, depending on purity and storage. This substance shows a crystalline texture—formulated as flakes, fine powder, or granular pearls. Some suppliers offer it as a liquid under certain temperatures, but the room-temperature form stays solid. Lab experience testing this material shows a melting point around 44–46 degrees Celsius and a boiling point near 266–267 degrees Celsius when measured under normal atmospheric pressure. The molecular weight (MW) clocks in at approximately 168.62 g/mol, and the density falls close to 1.17 g/cm³ as a solid.
Turning to solubility, 4'-Chloropropiophenone dissolves in common organic solutions like ethanol, methanol, and acetone, while water solubility sits low. This quality makes it easier for researchers to manipulate the substance during reaction processes or purification. Its stability under most standard lab conditions allows storage at ambient temperature, tucked away from moisture and sunlight. Still, the chlorine atom attached to the aromatic ring brings a certain reactivity, especially during substitution or oxidation reactions. Chemical industries take advantage of this reactivity by using it as a raw material in the synthesis of other value-added compounds.
The structural arrangement in 4'-Chloropropiophenone involves a three-carbon propionyl group linked to the benzene ring, with a chlorine substituent at the fourth carbon. This configuration opens up a range of transformation opportunities. In pharmaceutical labs, chemists value the compound for its ability to introduce specific molecular features via further chemical steps. If the industry needs intermediate compounds with aromatic chlorination, this molecule steps in as a favorite. Raw material buyers, especially those familiar with international shipments, should refer to the Harmonized System (HS) Code, which usually falls under 29143990 for customs and regulatory purposes, covering chlorinated aromatic ketones.
Specifications for product quality include not just purity (often 98% or higher in analytical applications) but also minimum traces of related impurities. Storage requirements focus on dry, well-ventilated spaces and the avoidance of extremes in temperature. Properly labeled, secure packaging in fiber drums or plastic bags prevents accidental spills and contamination. Material handling sheets often describe the product as crystals or powder, and my own time managing lab stocks taught me the importance of using gloves and protective eyewear. 4'-Chloropropiophenone may not release noxious fumes at room temperature, but inhalation or skin contact does pose health risks if best practices aren’t respected.
Safety remains a top priority during storage, transport, and disposal. Like many raw materials containing halogens and aromatic ketones, this compound deserves careful respect. Hazards include skin irritation, possible eye discomfort, and inhalation risks if dust forms during measuring or mixing. Any contact should be taken seriously, with lab coats and gloves mandatory, along with good ventilation. Industrial settings have seen cases where fine particles became airborne during grinding or weighing—leading to headaches or mucous membrane effects among unprotected staff. Fire risk does not present itself under normal handling, but the product should stay far from open flames and incompatible agents like strong oxidizers.
Environmental managers watching chemical inventories need to make sure 4'-Chloropropiophenone doesn’t make its way into public water systems or open ground. Waste streams destined for incineration or specialized collection prevent local contamination. Chemical spills call for dry absorbent collection and prompt disposal under strict hazardous waste codes, rather than regular waste channels. Regular safety drills remind workers not to underestimate any powdered or flaked chemicals, especially those with reactive halogen atoms. Long experience in lab and warehouse roles proves that clear labels, solid policies, and easy access to safety data sheets make for a safer environment.
The demand for 4'-Chloropropiophenone arises in research and industry routes alike. Pharmaceutical developments tap into its structure for the introduction of chlorine at the para position—enabling medicinal chemists to tweak biologically active scaffolds. Pesticide and herbicide innovation finds value in the same aromatic chlorination, using the intermediate as a stepping stone for active ingredient production. My firsthand dealings with chemical suppliers have shown a steady increase in interest from firms seeking reliable raw materials for pilot plants and commercial synthesis. Quality differences can mean the success or failure of a batch reaction, making supplier reliability and lot traceability more than just buzzwords—they mark the difference between high yield and costly setbacks.
Across the market, purity grades and formal specifications impact not only chemical performance but also downstream insurance of safety and regulatory acceptance. Teams that invest in high-grade, well-documented 4'-Chloropropiophenone build trust with their end-users, reducing risks of contamination in the resulting medicines or crop protection tools. Programs that integrate chemical management, continuous supplier audits, and solid safety training show stronger track records for sustainable growth. Rules for chemical transportation and storage have tightened recently, leading to better packaging, clearer hazard communication, and more consistent compliance with international standards.
A big part of responsible chemical use comes down to education and openness across the production chain. Newcomers in research or industry roles should take time to review basic chemical safety principles, and managers must make access to hazard documentation as easy as grabbing a coffee mug. Facilities can choose to participate in voluntary health and safety audits, ensuring that everyone knows how to handle emergencies or unexpected exposures. Waste minimization efforts, sealed containers, and regular maintenance checks contribute to better operational habits when dealing with solid or liquid stock. My own take: even experienced staff pick up new tricks during routine training updates—greater protection and efficiency spring from small, incremental improvements over time.
Initiatives focused on green chemistry also stand out. Where possible, consider designing synthesis routes that minimize waste, use less hazardous solvents, or enable recycling of chlorinated byproducts. These approaches reduce overall environmental burden and give companies a stronger story to share with customers and regulators. Teams that invest in automation for weighing, dispensing, and packing raw chemical powders cut down on accidental exposures. Industry advancements in real-time monitoring, barcode tracking, and better ventilation further strengthen staff well-being and environmental stewardship. Every ounce of care spent on selecting, storing, and handling 4'-Chloropropiophenone supports not just productivity but also the broader responsibility of keeping workplaces and ecosystems healthy.
