4-Bromo-2,6-difluorobenzoyl chloride belongs to the class of benzoyl chloride derivatives, standing out for its unique combination of halogen elements. The compound’s structure features a benzene ring substituted with bromine at the fourth position and fluorine atoms at the second and sixth positions, bonded to a carbonyl chloride group. This compound appears as a solid at room temperature, often found in crystalline or powdered form. Capping it off, the chemical formula reads C7H2BrClF2O, marking it as a specialized reagent among halogenated aromatic compounds.
A closer look reveals a compound with tangible characteristics. In its pure form, 4-Bromo-2,6-difluorobenzoyl chloride presents as white or off-white flakes, sometimes resembling pearls or fine powder. Density stays in the range common to halogenated aromatic solids, offering stability and ease for measurement by gram or liter. Its solid state resists quick dissolution in water, yet dissolves more readily in organic solvents. Crystals carry a sharp, distinct odor, signaling the presence of an acyl chloride functional group, which often brings with it reactivity toward nucleophiles. These physical attributes make it manageable for standard laboratory practices, although proper storing in a moisture-free environment becomes crucial to avoid unwanted hydrolysis.
The specific molecular weight of 4-Bromo-2,6-difluorobenzoyl chloride clocks in at approximately 257.44 g/mol, reflecting the presence of heavy halogen substituents on the benzene core. The density gravitates close to 1.6 g/cm3, depending on purity and crystal packing. As a regulated raw material, the compound commonly falls under an HS Code such as 291639, grouping it among acyl chlorides for customs and international trade. Each lot shipped by reputable suppliers comes with a certificate of analysis, verifying aspects like purity (typically above 98%), melting point (which helps confirm identity), and any presence of residual solvents.
Use of 4-Bromo-2,6-difluorobenzoyl chloride revolves around its powerful acylating ability. Industry and research tap into this property to synthesize specialty pharmaceuticals, advanced polymers, and agrochemical intermediates. The benzoyl chloride backbone, enhanced by electron-withdrawing bromine and fluorine, enables selective transformations in organic synthesis. Chemists treat this product as a valuable building block, bringing precision to complex molecular construction, especially in medicinal chemistry and materials science. The flakes or powdered solid dissolve in chlorinated solvents or aromatic hydrocarbons, allowing direct handling for reaction scale-up or batch adjustments.
Every acyl chloride—4-Bromo-2,6-difluorobenzoyl chloride included—presents challenges in safe use. Direct contact leads to burns, irritation, or toxic effects if inhaled or absorbed through skin. Its reactivity with water liberates hydrogen chloride gas, which poses respiratory hazards in poorly ventilated areas. Most facilities train personnel to use gloves, goggles, and work within fume hoods, reducing accidental exposures. Storage requires airtight containers, away from moisture, with labeling that reflects both chemical properties and risks of harmful reactions. As a hazardous material, transport obeys international guidelines, often marked with clear hazard pictograms, ensuring everyone involved treats it with the respect due a reactive, harmful substance.
On the industrial floor, 4-Bromo-2,6-difluorobenzoyl chloride earns a spot as a vital raw material. Its flake, solid, or powder form permits easy measurement without spillage, and solutions prepared in organic solvents allow for controlled dosing into reactors. Some plants opt for liquid or even crystalline presentations, depending on manufacturing needs and process integration. Research and scale-up teams focus on material compatibility, taking into account the molecular structure’s tendency to hydrolyze. Companies depend on clear labeling, up-to-date safety data sheets, and robust process controls to maintain consistent quality from raw material to finished output.
Working in chemistry brings a unique respect for substances like 4-Bromo-2,6-difluorobenzoyl chloride. Stringent controls around storage and transfer help avoid costly or dangerous incidents. Investing in reliable ventilation and regular staff training goes a long way toward safer workplaces. Some organizations explore enclosed automation to reduce direct contact, leveraging remote monitoring and dispensing technology. Waste streams containing halogenated byproducts require specialized neutralization and disposal under environmental safety protocols. The pursuit of greener alternatives or recycling methods for chlorinated raw materials remains a goal among forward-thinking operations.
