4-Bromo-2,3,4',5-tetrafluorobiphenyl belongs to the class of halogenated biphenyl compounds, which scientists trace for both their distinct stability and their use as versatile intermediates in technical and chemical synthesis. The chemical formula is C12H3BrF4, and the structure features a biphenyl core, where four fluorine atoms and one bromine atom come together across the paired rings. This molecule combines the high electronegativity of fluorine with the reactivity of bromine, pushing it into a growing niche where complex aromatic compounds support research and industrial formulation.
This compound presents as a solid under standard laboratory conditions. Each aromatic ring bears specific substituents: fluorine atoms enhance the chemical’s resistance to metabolic breakdown, while the bromine gives it a reactive site for further functionalization. Density for 4-Bromo-2,3,4',5-tetrafluorobiphenyl often registers near 1.7 g/cm3, fitting its close-packed aromatic rings and heavy halide components. Fine crystalline powder or flakes is the most routinely encountered form, reflecting the molecular regularity and high melting point typical of substituted biphenyls. With use in mind, the low solubility in water becomes a key feature, so handling requires suitable organic solvents, especially for those preparing analytic standards or custom synthesis pathways.
In the lab, 4-Bromo-2,3,4',5-tetrafluorobiphenyl may appear as colorless to off-white crystalline solid, rarely showing visible impurities if properly handled. The shape—often as brittle flakes or crystalline powder—suggests a strong intermolecular structure, tightly bound by the halogenated rings that resist easy melting or vaporization. This resilience makes it valuable as a raw material; it does not easily break down under light or heat, and the physical form stays consistent with careful storage away from strong acids or bases that could attack the halide groups. Synthesis teams appreciate that its uniform flakes disperse well in solvent-based reactions or in setups demanding a persistent solid phase.
Demand for specialized biphenyls traces back to both academic research and sectors focused on OLEDs, specialty plastics, and advanced pharmaceuticals. 4-Bromo-2,3,4',5-tetrafluorobiphenyl steps in as a building block. Its high-purity profile, frequently above 98%, lets research chemists rely on its stability for cross-coupling reactions, especially in Suzuki or Stille protocols that need a halogenated aromatic foundation. Consistent melting point, sharp NMR and IR spectra, and a clear material safety data record contribute to confidence in scaling applications. Modern factories request tight controls on particle size, moisture content below 0.5%, and absence of related impurities—standards driven by both production need and international regulations.
Globally, tracking through trade and customs falls under HS Code 2903999090 for halogenated aromatic hydrocarbons. Compliance puts suppliers and buyers on firm ground with chemical control agencies, easing transfer across borders. Safety documentation always travels with shipments, including CAS number references, batch purity, and recommendations for safe storage. Both upstream raw materials and this finished product fall under review for environmental impact, especially where halogenated organics play a role in downstream synthesis. Adhering to chemical regulations like REACH in Europe and tracking safety status in the United States and Asia keeps legitimate commerce steady and addresses global concerns about persistent organic pollutants.
Working with brominated and fluorinated aromatics means reviewing safety first, as both chemical and physical hazards exist. Dust can irritate the respiratory tract if handled without a mask or glove protection. Direct skin contact with the solid or dusty powder may cause mild irritation. No one should ingest, inhale, or allow eye contact, so controlled environment, working fume hoods, and disposable lab apparel are standard. On the accident spectrum, this molecule is not flammable under typical storage, but combustion releases hazardous gases including hydrogen bromide and toxic fluorides, demanding both active and passive fire suppression where stocks are present. Waste streams divert for high-temperature incineration or specialized hazardous waste disposal, not general lab sinks or municipal waste, following requirements for halogen-containing organics.
Tightening regulations on halogenated aromatics increase oversight. Researchers see more stringent controls on shipping, and rising costs for specialized disposal push some to seek safer alternatives. Yet the compound’s unique reactivity ensures ongoing need, especially where generic biphenyls cannot substitute. Digital tracking, clear labeling, and centralizing chemical inventory in compliant warehouses present real solutions, keeping accidental releases rare and ensuring rapid recall if a batch fails safety criteria. Integrating best practices—regular staff training, updated instrumentation, and close attention to solvent compatibility—keeps workflow efficient, people protected, and the supply chain secure from both human error and regulatory action. For anyone involved in materials science, fine chemicals production, or advanced analytics, addressing the risks without losing sight of the real scientific value creates opportunity to grow both safety culture and innovation together.
