4,6-Dichloro-2-(propylthio)pyrimidin-5-amine shows up as a specialized organic compound with the molecular formula C7H9Cl2N3S. The structure falls under the pyrimidine class, with chlorines attached at positions 4 and 6, and a propylthio group locked in at position 2. That extra amine group on the pyrimidine ring means it can slip neatly into a chemical reaction when given the right partner. I’ve handled this compound both as a solid flake and as a powder. Most chemists see something with a pale white or light yellow color, sometimes forming low-density crystalline solids. These flakes or crystals dissolve well in organic solvents like dichloromethane but resist most water-based solutions. If you weigh it out in the lab, you smell a faint chemical tang, not as sharp as some pyrimidine derivatives, but noticeable if the jar has been open a few minutes.
The presence of two chlorine atoms, an amine, and a propylthio chain gives this molecule a real edge when temperatures change. It melts at temperatures typically above 100°C, sometimes holding together until almost 130°C before beginning to soften into a liquid. In the solid state, these molecules tend to pack loosely, which keeps the density on the lower side—usually hovering close to 1.47 g/cm³. Measuring density in a lab can vary, but that figure puts it in the range of other pyrimidine chemicals. I’ve seen it show up as small flakes and sometimes as rough, chalky powder. Anyone ordering large amounts as a raw material will notice it comes packed as free-flowing crystals or sometimes pressed into pearls for steady handling, depending on the synthesis process. In all forms, it keeps its integrity in dark bottles and doesn’t clump unless hit with heavy humidity.
Talking about specifications, manufacturers usually market it by purity—a lot of 97% or higher is common, though anything above 98% is top grade for active synthesis. It usually comes with a stated “loss on drying” below 1%, which keeps buyers confident that the product hasn’t soaked up moisture during transit. It stays away from water as much as possible, so solutions for actual use typically rely on solvents like N,N-dimethylformamide, dimethyl sulfoxide, or acetonitrile, with careful mixing at room temperature. The HS Code, which helps with regulatory and customs tracking, is most consistently listed around 29335995, falling into the broader “heterocyclic compounds” category. Tracking this information isn’t just paperwork. It keeps everyone safe and aboveboard when shifting chemicals across borders, showing exactly what’s being handled.
Working with 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine in any synthesis pushes safety to the front of the mind. The compound stays stable under ordinary handling, but it reacts if exposed to strong acids, bases, or oxidizing agents. Gloves and goggles live on my bench while measuring out these flakes, since dust or dissolved material can cause skin or eye irritation. Material Safety Data Sheets always list it as potentially harmful if swallowed or inhaled, so I use a fume hood even if it’s just for routine weighing. Its main hazard lies in its reactivity—for example, if dropped into strong oxidizers, it can produce corrosive gases or heat. Spills need careful cleanup without just sweeping up flakes. Proper labeling and keeping it in tightly sealed containers prevents accidental release or mixing with incompatible chemicals. Disposal routes follow hazardous chemical protocols—nothing should hit the sink or ordinary trash. Every major supplier, especially those shipping at the ton scale, stamps each batch with hazard pictograms for acute toxicity and environmental risk, keeping users alert that this material, like many in organic synthesis, commands respect.
Most research and industry projects use this compound as a building block for further chemical transformation. It’s rare to see it as a final product. For anyone developing new pharmaceuticals or agricultural chemicals, this particular pyrimidine derivative offers a reliable starting point. The chlorine atoms make sites available for nucleophilic substitution, while that propylthio group allows for tailored modifications—and the amine sticking out gives another handle for custom reactions. Because of this flexibility, it finds itself in the middle of multi-step syntheses. In fact, several patent filings and academic papers highlight the use of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine as a precursor for designing molecules that target biological pathways, especially in fungicides and antiviral drugs. From my experience, success in synthesizing target molecules using this raw material boils down to strict environmental controls—dry workups, measured heating, and safeguarding against cross-contamination.
Sourcing high-purity 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine takes a balance. There’s always the issue of minimizing impurities that might derail downstream synthesis. It also brings up discussions about safe transport and storage—in tightly sealed glass or HDPE containers, away from direct sunlight and damp conditions. For large-scale handling, ventilated spaces and spill kits remain vital in every facility. From an environmental perspective, any waste associated with production or spills can fall under hazardous waste rules, which means disposal routes must minimize risk to both people and water supplies. Looking for ways to make the synthesis greener, such as using less toxic reagents or recycling solvent streams, helps keep up with growing regulations on chemical safety and environmental footprint. Raising awareness among staff, focusing on clear labeling, and following up-to-date safety practices help lower the harm risk, both in personal health and the wider community. By focusing on best practices and continually reviewing ways to cut down hazardous materials, facilities can limit their impact while still meeting industrial and research demand for reliable, high-purity pyrimidine compounds.
