2,4-Difluoro-3,5-dichloroaniline stands out among specialty chemicals because of its structure: a benzene ring substituted with two fluoro groups and two chloro groups, along with an amino group that anchors it within the family of anilines. It doesn’t come up in everyday conversation, but for people working in agrochemicals, pharmaceuticals, or chemical research, this compound supports the framework for more complex molecules. The molecular formula is C6H2Cl2F2NH2, giving it a molecular weight of 199.99 g/mol. In most laboratories, it appears as a solid crystalline material, and depending on purity or storage, you might find it as small flakes, crystals, or a fine powder.
The structural formula paints a clear picture: the benzene ring hosts chlorine atoms at the 3 and 5 positions, fluorine atoms fixed at the 2 and 4 positions, and an amino group (-NH2) directly attached at the first carbon. That arrangement gives the compound a unique reactivity profile. The specific density usually falls around 1.54 g/cm³, measured at standard lab temperature. Its melting point sits between 75-78°C, and it starts to decompose near 200°C, releasing toxic fumes characteristic of halogenated anilines. People handling the raw powder note its off-white or light tan color; as a crystal, it reflects light weakly and remains almost odorless.
Producers typically supply 2,4-Difluoro-3,5-dichloroaniline in sealed drums or polyethylene-lined bags, keeping out moisture and sunlight. Lab quantities arrive in glass bottles as crystalline solids or flakes, while factories prefer larger volumes as powder or sometimes pressed pearls for easier dosing. Due to its moderate solubility in organic solvents like dichloromethane or ethanol, chemists use it both as a process intermediate and for preparing custom solutions. It remains nearly insoluble in water, a trait that impacts both handling and waste disposal methods.
To clear customs, suppliers assign the HS Code 292142 for aromatic monoamines containing halogens. This number streamlines international shipments, but regulations can shift depending on local safety ordinances or intended use. Typical product specs include a minimum purity of 98%, moisture content under 0.5%, and strict limits on related halogenated anilines. Shipping relies on certified UN-approved containers since the material falls under ‘hazardous goods’ status, reflecting its chemical hazard properties and handling risks.
Anyone handling 2,4-Difluoro-3,5-dichloroaniline faces real risks: both chlorine and fluorine groups crank up reactivity and toxicity. Direct contact can irritate skin or eyes, and inhaling dust or fumes triggers respiratory symptoms. Wearing gloves, goggles, and splash-resistant coats can’t be skipped. In case of accident, thorough washing with water and prompt medical attention become practical steps. Long-term exposure links to possible liver and kidney impact because many halogenated aromatic amines cause systemic toxicity over time. Material Safety Data Sheets highlight the need to store it in a cool, ventilated area, away from acids, bases, and oxidizing agents that can provoke dangerous reactions.
This compound matters because it supports the synthesis of herbicides, fungicides, and fine chemicals. The halogen atoms add stability and alter biological activity in end products, feeding into downstream compounds with improved selectivity. Medicinal chemists explore modifications of this core structure to discover new antimicrobial or anti-inflammatory agents. Over the past decade, data pulled from patent filings show a steady increase in derivatives of 2,4-Difluoro-3,5-dichloroaniline, especially for crop protection agents, where robust weeds push chemical development forward.
It’s not enough to focus on short-term gains from compounds like this. Using halogenated anilines shapes the environmental footprint of chemical industries. Waste treatment calls for specialized incineration or advanced oxidation due to the formation of persistent byproducts; regular industrial wastewater systems rarely cut it. Smart companies install closed-loop solvent recovery and track air emissions from weighed or heated products. Researchers interested in greener chemistry push for alternatives and safe degradation pathways, but switching away from such a central raw material involves major lab and plant overhauls. Transparent reporting and real-time monitoring help teams catch accidental releases early and support community trust.
Routine chemical handling won’t shield people from hazards unless companies commit to robust training, up-to-date safety gear, and real accountability. Engineers in large-scale plants scrutinize reaction conditions and pack designs to cut waste—reducing contact between workers and pure material. In university labs, digital logbooks and direct supervision make sure procedures don’t tempt shortcuts. Professional bodies regularly update protocols that reflect new findings about long-term effects and cross-reactivity. Scientists and policy makers can’t sidestep chemicals this useful, but everyone can advocate for safe handling, waste control, and early investment in alternatives that promise similar performance with fewer downsides.
