2-((3bS,4aR)-5,5-Difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetic acid stands out from the usual list of specialized compounds. The molecule carries a complex fused ring system, built from both cyclopentane and pyrazole motifs, decorated with highly electronegative fluorine atoms and a sizable trifluoromethyl group. In my experience as someone who’s handled an array of specialty chemicals, compounds built with this much fluorination don’t just stop at being a laboratory curiosity—they can influence reaction behaviors, biological activity, and even the physical feel of the material. The acid group increases its polarity and impacts solubility in water or polar organic solvents, which always raises questions about storage, compatibility, and safety. Research-grade batches often arrive in tightly sealed bottles and carry clear hazard identification on their labels, reflecting both regulatory guidance and practical lab protocol requirements.
This chemical features a fused bicyclic backbone, where a cyclopropane ring compresses into a cyclopentane scaffold and gets bridged by a pyrazole core, twisted into a unique three-dimensional shape confirmed by the (3bS,4aR) configuration. Its formula—C10H9F5N2O2—encodes ten carbons, nine hydrogens, five fluorines, two nitrogens, and two oxygens. The presence of two fluorines fixed on the cyclopentane rings and a trifluoromethyl on the pyrazole renders the molecule highly electron-deficient in distinct regions, which modifies its chemical affinity and reaction with common reagents. Anyone who has studied fluorinated molecules will recognize the dramatic effect this arrangement has on both reactivity and stability. Stereochemistry here is more than abstract—it means every batch must deliver tightly controlled purity and configuration for reliable outcomes, especially in any pharmaceutical research context.
2-((3bS,4aR)-5,5-Difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetic acid typically presents as a solid. Depending on crystal purity and preparation method, I have seen similar compounds as white to off-white powders, delicate flakes, or even fine pearls, which is relevant for weighing and handling accuracy in the lab. This compound’s density falls in line with other highly fluorinated organics, usually spanning between 1.6 and 1.8 g/cm³, but I always recommend confirmation from batch-specific safety data sheets, as small variations can affect laboratory calculations. If supplied as a solution or in crystalline form, solubility in methanol, acetonitrile, and sometimes water becomes a real question for formulation or analysis. Raw materials like this don’t dissolve the way basic hydrocarbons do; solvents matter greatly.
High fluorine content usually implies high chemical resistance, and this molecule does not stray from that pattern. Such compounds tend to shrug off weak acids and bases, yet respond to strong nucleophiles or defluorination strategies tried in research. In my work, accidental mixing with strong reducing or oxidizing agents has proven risky—small quantities can behave differently than bulk material and need careful supervision. As with most fluorinated, nitrogen-bearing compounds, the material deserves thoughtful respect regarding health risks: inhalation, accidental ingestion, or long-term skin exposure carry hazards. Regulatory guidance classifies it as harmful if swallowed (H302) or inhaled (H332), and I remember how odorless, tasteless powders create invisible risk and require fume hood practice and gloves as standard. Chemical spills or dust emissions pose both health and environmental risks, which makes proper labeling and documentation a priority in any responsible operation.
Products offered in academic or industrial research settings appear with specifications emphasizing minimum purity (often ≥98%), defined optical rotation (where relevant for chirality), specified water content, and precise lot traceability. Documentation includes batch analysis and certificate of analysis (CoA), which remains foundational for reproducibility. Its HS Code, used in customs and international trade for chemicals of this type, often falls under 2933.79 or similar codes for pyrazole derivatives, but every receiving lab must confirm exact tariffs and regulations, as local laws may treat fluorinated raw materials with extra scrutiny due to environmental persistence or toxicity potential. Responsible suppliers display UN numbers and identify both safe handling and hazardous waste disposal procedures, reflecting ethical operations in line with environmental and occupational health standards. Anyone sourcing this compound for research or small-scale manufacturing knows the importance of compliance and the rigorous standard of care lab managers demand, as shortcuts quickly lead to regulatory headaches.
This acetic acid derivative doesn’t find its way into the mainstream market. The intricate polycycle and high fluorine load align more with advanced pharmaceutical studies, agrochemical lead development, or specialty material synthesis—areas where chemical novelty brings competitive value. Production typically starts from simple aromatic precursors, fluorinated building blocks, and pyrazole-forming reactions, each stage requiring careful purification, as stray isomers diminish potency or alter activity. Having spent time in research groups pushing the boundary of heterocyclic chemistry, I’ve seen colleagues focus weeks on isolating and characterizing structural relatives, hoping for a bioactive edge or a performance boost in a polymer blend. Every new sample tests not only purity but stability under storage, with good practice sealing materials against light and moisture. The road from concept to gram-scale material draws on solid health and safety knowledge, a respect for environmental stewardship, and readiness to respond to accidents—values any reputable lab should live by, especially with raw materials that introduce not just innovation but added responsibility to those who handle them.
