(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride stands out in chemical manufacturing as a highly specialized organic compound. Chemists recognize it by its unique structure: a cyclopropane ring bonded to a 3,4-difluorophenyl group, finished with a primary amine, then paired with a hydrochloride moiety. Its molecular formula reads as C9H10F2N•HCl, forming a dense and well-defined molecular framework. Laboratories often classify substances like this by their CAS identification number and HS Code, with the latter crucial for customs and regulatory purposes in international trade. The product’s purity and composition influence its application and safe handling practices, so reviewing batch analysis and certificates matters to users and suppliers alike.
As a solid material, (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride usually appears as off-white to pale yellow flakes or crystalline powder. Handling it feels much like working with other powdered raw chemicals, but subtle characteristics—such as density, particle size, clumping tendency, and even static charge—can impact its storage and use. In some batches, fine granules resemble small pearls or crystalline shards, and users need to consider hygroscopic behavior, since moisture in the air has the potential to alter the product’s stability. Chemically, the presence of both cyclopropanamine and difluorophenyl groups shapes the compound’s reactivity and solubility. While hydrochloride salts typically dissolve well in water and polar solvents, actual user experience often reveals differences in dissolution rates or cloudiness based on temperature, pH, or impurity levels. This matters, since clear solutions in measured liters or calibrated vessels are routine requirements in laboratory and production settings.
Diving into the molecular level, the cyclopropane ring offers rigidity, while two fluorine atoms at the 3 and 4 positions of the benzene ring contribute both electronegativity and metabolic stability. This places the compound into a class of molecules valued for resilience during synthesis and downstream processing. Molecular weight, at approximately 209.64 g/mol (hydrated form), helps users plan dosages when used as an intermediate or reagent. Labeling always specifies batch number, lot details, and the measured density—not just nominal. Safety data sheets give melting point, which commonly falls between 168-174°C, as well as solubility specs for both aqueous and organic systems. Whether stored in jars, sealed foil bags, or under nitrogen, maintaining proper conditions ensures long shelf life and consistent quality for demanding applications.
International shipping and regulation identify (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride through its HS Code, typically under the heading for organic chemicals with amine and aromatic functionalities. Correct categorization under relevant codes allows for transparent trade, helps suppliers and buyers avoid customs disputes, and supports compliance with national safety frameworks. As someone who has managed chemical imports and exports, this accuracy in paperwork prevents shipment delays, contributes to supply chain security, and levels the playing field for legitimate buyers and researchers.
Handling any hydrochloride salt warrants good respect for chemical safety, and (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride ranks no differently. The hazard profile includes potential skin and eye irritation, and, if mishandled, respiratory discomfort or more serious health effects. Detailed Safety Data Sheets lay out necessary precautions: gloves, protective eyewear, dust masks for weighing and transfer, and laboratory fume hoods for solution preparation. Proper waste disposal keeps laboratories and the environment clean, while spill protocols prevent exposure and contamination of workspaces. Many years dealing with chemical raw materials have taught me that reviewing hazard pictograms and risk phrases is not bureaucracy—it forms the backbone of worker health and process reliability.
For synthetic organic chemistry, pharmaceutical R&D, and agrochemical innovation, (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride delivers value as an intermediate. The chiral nature—reflected in the (1R,2S) designation—guides its application where stereochemistry can change the outcome of a synthesis or pharmacological test. Whether in catalyst development, building block assembly, or final formulation screening, the substance’s availability in various solid forms (powder, flakes, pearls) allows selection based on what the process requires. Access to detailed specifications and analytical data makes supplier choice easier for teams under time pressure in process labs or pilot plant settings.
Some common difficulties connected with using chemicals like this relate to assurance of purity, regulatory compliance, and sustainability of supply. Reliable suppliers need to support their materials with full spectra, traceability records, transport documentation, and rapid technical support. Companies can invest in employee training and in-house testing to reduce risk and ensure product meets all required performance standards. Exploring more robust packaging, desiccants, and climate-controlled storage can solve stability and shelf-life concerns, especially for high-value batches where degradation means lost revenue. Advancing towards green chemistry, researchers aim to refine synthetic routes, limit hazardous waste, and recycle solvents, pushing the industry toward safer and more environment-friendly practices in future development work.
