(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-mandelate stands out among specialty organic chemicals, a complex molecule with layers of function and application. This compound draws attention in research labs focused on pharmaceutical advancement, not least because the cyclopropanamine group couples with a difluorophenyl ring, adding both stability and unique reactivity. Fluorine atoms on the aromatic ring typically boost metabolic stability, so anyone pursuing novel therapies or rigorous syntheses gets an edge in predictability and interaction with biological targets. The structure includes a chiral cyclopropane backbone and a mandelate salt, which signals enhanced solubility and distinct handling properties in the lab or production environments. These features shape the way researchers and industry professionals approach development, scale-up, and safety, a focus that aligns with ongoing changes in materials science and pharmaceuticals alike.
This compound usually appears as a solid at standard conditions, taking the form of white or off-white crystals, flakes, or possibly a powdered consistency depending on humidity, processing, or packaging methods. Its density depends on crystallinity and degree of packing during storage, but the typical solid structure offers convenience for weighing, partitioning into batches, or dissolving for downstream work. Crystals form cleanly in solution, and this property ties back both to the purity achievable in synthesis and to ways the solid can be measured for solution-phase reactions or storage stability. Its melting point, often sought out during quality control, serves as a benchmark for both chemical purity and suitability for specific formulations. Material scientists I’ve spoken with often test bulk density to streamline mixing steps in manufacturing, whether blending with solvents or converting to a liquid solution for fine measurement in pharmaceutical labs. The presence of the (R)-mandelate counterion means the compound dissolves more readily in polar solvents than the free amine, aiding analysts and chemists looking for straightforward solution preparation and handling. Raw material buyers look for precise values when ordering this substance, especially because density and phase affect logistics such as bulk transport, packaging choice, and safe delivery.
The molecular structure grabs attention, built from C10H11F2N•C8H8O3, summing up to a formula that reflects not only typical functional groups but the specific orientation of atoms—chirality here is not just a detail; it determines how the compound interacts with biological targets. Labs with a focus on stereoselective synthesis recognize the (1R,2S) arrangement as critical for downstream activity or compatibility with wider molecular libraries. The difluorophenyl moiety directs electronic effects, often lowering metabolic degradation compared to non-fluorinated analogs. The cyclopropanamine ring brings rigidity and a recognizable signature in NMR or other spectral studies, simplifying routine identity confirmation and quality checks. From a practical perspective, every raw material supplier needs to match the compound’s HS Code for customs, transport, and regulatory paperwork—often found within 2921 for amine derivatives, streamlining international sourcing and compliance audits. The presence of both aromatic and carboxylate groups not only impacts chemical reactivity, but also guides storage protocols, as these groups react differently under light, moisture, or air exposure compared to more robust alkane frameworks.
Workplace safety hinges on a real understanding of how chemicals respond to common mishaps. This compound, while valuable in research and pharmaceutical development, requires care in storage and use. The presence of both amine groups and a difluorophenyl ring calls for gloves and goggles—skin contact might bring irritation, especially over repeated exposure. Material Safety Data Sheets indicate the (R)-mandelate salt helps moderate volatility, but dust or fine particulate inhalation remains a realistic concern in bulk powder handling. I recall one incident in a university lab where static discharge sparked when weighing powdered amines, making proper grounding and sealed containers a non-negotiable step. Chemical supply chains document deemed-hazardous ingredients for transport under clear labeling—especially for export. Not all regions treat the risk profile the same, so international users stay attentive to local registrations and hazard classifications, often based on toxicity, environmental persistence, or flammability thresholds. Clean-up spills rapidly with filtration and neutralizing agents; in many cases, cyclone almondy odors from the mandelate signal area contamination. Fact sheets recommend room-temperature storage away from oxidizers or acids, limiting the formation of unwanted byproducts or potential hazard cascades. Disposal requires certified chemical waste haulers, as landfill or drain routines often fail environmental rules when aromatic amines or fluoride-labeled compounds get involved. Training and PPE protocols in laboratories and production lines reduce risk, preserve sample integrity, and protect long-term health, all essential to responsible use of this valuable but potent raw material.
Challenges in using (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-mandelate fall into two camps: safe laboratory workflow and compliant supply chain movement. Automated solid handling is growing, and businesses investing in robotics or closed systems see fewer exposure incidents as a result. Improved containerization—sealed, clearly labeled jars that resist moisture and static—brings peace of mind to both chemical storage staff and bench chemists. There’s also growing interest in digital tracking; barcodes tied to supplier, batch number, and hazard classification give clear records for audits and incident follow-up. On the academic side, students benefit from hands-on training with simulated hazards, not just rules read from a site manual. Industry and regulators are trying to close the gap between innovation and oversight by updating hazard communication frequently and requiring more transparent supply chain reporting. Labs are, on the whole, moving closer to zero-waste philosophies; recycling solvent from product separation, reclaiming spills, and tightly managing inventory help keep environmental impact lower. Safe access and informed usage—those factors keep research moving forward with compounds like (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-mandelate, turning raw material into meaningful outcomes for science and society.
