5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene: A Comprehensive Look

Historical Development

Chemists have steadily expanded the toolbox of fluorinated aromatic compounds, and 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene showcases just how far that craft has come. Fluorine chemistry really picked up speed in the 20th century after breakthroughs in the safe handling of elemental fluorine. Researchers have added to the catalog of organofluorines, pushing into complex, highly selective compounds. This molecule reflects decades of effort to control substitution patterns on benzene rings for more targeted properties. Each modification of the phenyl ring—adding bromine or positioning those difluoromethoxy groups—comes out of hands-on lab work, trial, error, and a constant dialogue between synthetic routes and the real needs of end-users, especially in materials science and pharmaceuticals. Most early syntheses started with easier substitutions and less intricate reagents, then slowly became more advanced as protection and selective coupling strategies improved.

Product Overview

In practice, 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene serves as a specialty intermediate for those who demand tight control over molecular architecture. I’ve seen it used where traditional phenyl ethers fall short, largely because it combines unusual electron density with halogen handles for downstream modification. It stands out due to its high fluorine content, which increases its chemical resilience, while the bromo substituent acts as a key handle for cross-coupling reactions. Anyone looking to combine stability with reactive functional groups in a single scaffold will find it fits that need.

Physical & Chemical Properties

So, what does this compound actually look like? The white crystalline powders that come out of the reaction batch tell you a lot about its purity and handling requirements. A dense aroma might suggest some volatility, though good lab practice means you’re usually not getting a whiff. Its melting point speaks to solid-state stability, and those fluorines actually make the molecule more hydrophobic than its non-fluorinated cousins. Chemically, the multiple electron-withdrawing groups modify the ring’s reactivity, pushing it to resist oxidative breakdown and making aromatic substitutions more selective. It’s not something you’d drop into water or common solvents expecting immediate dissolution; often, specialized fluorinated solvents or non-polar organics do the trick.

Technical Specifications & Labeling

Product data sheets for this compound don’t leave much to guesswork. Purity usually sits at 98% or better, with single-digit ppm levels for heavy metal contamination and moisture. Batch numbers and lot tracking ensure reproducibility in downstream applications. Most samples come with an HPLC or NMR trace attached, and if you’re working in regulated environments, Certificates of Analysis with standardized reference spectra back every purchase. Shipping labels warn about the halogen content and specify storage away from heat and direct light, as high-energy photons can trigger slow breakdown of the aryl bromide fragment.

Preparation Method

Lab prep often starts with a carefully protected precursor, building up the fluorinated benzene core through selective substitutions. Bromination of the aromatic ring under controlled temperature gives that precise 4-bromo position. The difluoromethoxy group doesn’t add itself easily; chemists usually tether it last, using strong bases and either cheap difluorocarbene precursors or difluoromethyl ethers in the presence of activating catalysts. Purification leans heavily on column chromatography and sometimes on recrystallization from hexanes or toluene to yield the clean white solid. Modern scaling benefits from microflow setups, cutting down on batch-to-batch variability.

Chemical Reactions & Modifications

Holding a bromo group at the para position opens the door to Suzuki or Buchwald-Hartwig couplings, and the difluoromethoxy group resists most nucleophilic attacks. Synthetic chemists can selectively functionalize the aromatic core, introducing amines, aryl groups, or heterocycles where needed. That’s a key benefit if you’re aiming to customize bioactive scaffolds or swap substituents for property tuning in electronic applications. I’ve seen partners use this backbone for late-stage functionalization, exploiting its unusual resistance to hydrolysis and oxidation, perfect for when your process can’t risk side reactions. Even direct fluorination or oxidative couplings become feasible with proper protection and activation steps.

Synonyms & Product Names

You might see this compound sold as “Bromo-difluorophenyldifluoromethoxytrifluorobenzene” in catalogs, but chemists working with it often refer by shorthand: “BDFP-DMB-TFB” or just the molecular code if you’re in a high-throughput screening lab. Any supplier serious about regulatory compliance keeps CAS numbers consistent across labels, meeting international tracking requirements. In application notes, researchers stick to systematic naming for publication clarity.

Safety & Operational Standards

Nobody should take the handling of halogenated aromatics lightly. Gloves, face shields, and chemical fume hoods all stay in play when opening a new bottle. This compound doesn’t burn skin or eyes as harshly as more reactive halogen organics, but the chronic toxicity of fluorinated fragments gets flagged in every MSDS. Waste streams containing this product go through halogen destruction protocols, since environmental persistence remains a real issue. Any lab prepping batches has to keep spill control kits within arm’s reach and train staff in first-response decontamination. Full compliance with GHS labeling distinguishes good suppliers from unsafe ones.

Application Area

Advanced materials research pulls most demand for this molecule. Organic electronic developers appreciate its stable, high-resistance structure—it’s a go-to building block in OLED and OFET design, allowing precise tailoring of charge mobility and lattice packing. I’ve seen R&D teams also chase patent-protected applications in targeted pharmaceuticals, especially where metabolic resistance and improved solubility profiles edge out older scaffolds. High-value agrochemical research stakes a claim, seeking new modes of pesticidal action with lower off-target effects. Anyone chasing fluorine’s unique balance of lipophilicity and metabolic stability has this structure on their radar, whether tweaking dyes, polymers, or small molecule drugs for tougher environments.

Research & Development

Hands-on researchers keep exploring its potential for new C–C coupling techniques, green chemistry syntheses that cut out hazardous reagents, and custom formulations. Solid-state chemists and spectroscopists probe crystal packing and hydrogen bonding changes brought on by heavy fluorination—a field where surprises crop up more often than classic textbooks would suggest. Analytical teams push refinement in quantifying trace-level impurities in the finished molecule, using high-resolution NMR and advanced LC-MS methods. Programs gaining traction in the last decade involve automated synthesis robots that churn out libraries with varied substitutions, all built on this robust skeleton.

Toxicity Research

Nobody ignores the potential harms of polyfluorinated compounds anymore. Regulators keep a close watch, especially after the headlines surrounding persistence of PFOA and PFOS in groundwater. Ongoing animal studies and in vitro cellular assays monitor how these molecules break down—usually slowly—and what residues linger in tissues. Acute toxicity studies haven’t flagged major red alerts at typical exposure levels for research staff, though ecological studies flag concerns about cumulative buildup and unknown breakdown products. Practitioners keep batch sizes low, enclose experiments, and push for rapid waste neutralization. Bioaccumulation risk shapes every disposal guideline and incentivizes the hunt for less persistent derivatives in next-generation designs.

Future Prospects

Chemists and engineers keep pushing this molecule’s boundaries, especially as demand grows for tougher fluorinated materials in harsh environments and more selective receptor modulators in biomedicine. Sustainable synthesis draws real funding now, steering labs away from old-school halogen-heavy solvents and chasing process innovations that reduce persistence issues. Collaboration between industry and academia could lead to less-toxic analogues or degradable substitutes. The next steps involve systematizing long-term toxicity data and encouraging wider open-access research so everyone can anticipate both the breakthroughs and the risks. Anyone who cares about the intersection of utility and responsibility sees this challenge as a generational one, blending high-performance chemistry with a focus on stewardship.



What is the chemical structure of 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene?

Getting Closer to Complex Molecules

Chemical names like 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene tend to intimidate people outside scientific fields. Learning the structure behind such substances, though, gives a much clearer sense of how small molecular changes shape the world. For chemists, knowing the arrangement of atoms in a molecule is more than academic; it guides drug development, influences environmental research, and steers industrial applications.

Breaking Down the Basics

Every line in the name lays out structural clues. The benzene at the end points to rings of six carbons with alternating double bonds — a shape familiar to anyone who’s ever looked at aspirin, Tylenol, or even the humble dye molecules in blue jeans. Chlorine, bromine, and fluorine stand out among the halogens for their unique chemical personalities. This compound carries fluorine atoms at three places on one benzene ring, and additional fluorines along a difluoromethoxy bridge attached to a different aromatic ring with its own bromine and fluorine substitutions. Structurally, you get two linked benzene rings, dotted with halogen atoms that tweak how the molecule acts.

Structure Shapes Properties

Fluorine packs a punch for its size: it resists chemical attack, pulls electrons towards itself, and can increase metabolic stability or block degradation, which becomes crucial if you want a molecule to stick around in a drug or coating. Bromine isn't as small or electronegative but brings heft and changes how the molecule interacts with other systems. Pair that with the benzene rings, and you’re looking at a molecule that likely resists breakdown, repels water, and could pass unnoticed through biological barriers — all traits that play into pharmaceutical, agrochemical, and even materials science research.

From Chemistry Lessons to Real-World Impact

Studying such molecules goes well beyond satisfying curiosity. Many pharmaceuticals use rings loaded with halogens to tip the balance between activity and stability. That push for better-matched molecules doesn’t just boost bottom lines; it can mean fewer side effects or a longer shelf life for critical medicines. On the other hand, stability also raises concern about persistence in the environment. Many stable aromatic compounds, especially those bristling with fluorines, stick around in soil and water, resisting natural breakdown. Chemists and regulators have tangled with this issue from pesticides to flame retardants, so understanding structure helps guide green chemistry efforts as well.

Solutions Through Smart Chemistry

Having studied organic chemistry in university and watched research labs wrestle with molecule design, I've seen how structure informs every step of the discovery process. Groups working on new drugs or environmentally safer alternatives start by mapping how each functional group — like the trifluorobenzene core or the bromodifluorophenyl chain — changes the outcome. Analytical tools such as NMR spectroscopy and X-ray crystallography give concrete maps of where each atom rests, helping chemists design more targeted, safer, or more effective compounds. Policies can step in to guide research: incentivizing molecules that perform the job but degrade harmlessly when discarded, or tracking persistent molecules so they don’t build up in food chains or water supplies. Ultimately, every new name and structure in chemistry shapes reality — sometimes with effects that reach far beyond the lab.

What are the typical applications or uses of this compound?

Fueling Daily Life with Practical Chemistry

People might not pause to think about where certain materials come from or why simple things just work. But most products used daily rely on just a few essential compounds doing their job behind the scenes. Take sodium bicarbonate, for example. Most would know it better as baking soda, and it's hard to overstate its reach. As someone who likes to cook and keeps a keen eye on cleaning hacks, I see firsthand how often this unassuming powder comes up in household advice, recipes, and even science experiments with kids.

In the Kitchen

Baking soda makes bread and cakes rise. Without it, the kitchen would be a different place. Its alkaline properties let it react with acids in recipes, creating carbon dioxide bubbles that give dough its soft texture. Beyond that, cooks lean on it for neutralizing acidic foods and speeding up the browning of onions or other staples. For anyone who has struggled with tough beans, adding a pinch to the cooking water can work wonders. These small tricks come from years of collective trial and error, handed down through families, and later, confirmed by food scientists.

Cleanup Crew

The cleaning aisle highlights sodium bicarbonate’s role as an accessible scrub and odor absorber. Whether sprinkled on carpets or combined with vinegar for a bubbling bathroom cleaner, it offers a safer choice compared to harsh chemical cleaners. Folks like me, with pets and kids around, appreciate this—simple cleaning that allows a home to smell fresh without overwhelming scents or danger if someone touches a just-cleaned surface. Hospitals and schools often embrace it for this reason. Its use isn’t just about tradition; it comes from real concern for indoor air quality and sensitive skin.

Health and Hygiene

Dentists have endorsed sodium bicarbonate’s mild abrasiveness for decades, and toothpaste tubes still list it high among ingredients. It manages coffee stains and freshens breath. My grandmother swore by a pinch of it in a cup of water to settle an upset stomach—a practice many doctors still mention for relief from mild heartburn. Beyond toothpaste, home remedies for insect bites or mild rashes often start with a little baking soda mixed with water. Here, science backs up the folk wisdom: sodium bicarbonate can buffer acids on the skin.

Industrial and Everyday Science

Beyond home and health, this compound shapes manufacturing and environmental work. Water treatment plants across cities dose it to keep pH in check, protecting pipes and making drinking water safer. The fire department on my street carries dry chemical extinguishers using it, ready for grease and electrical fires in kitchens or garages. Its low cost and predictable reaction patterns mean factories trust it for cleansing chemical spills or cleaning up after accidental acid dumps.

What Matters in Using These Compounds

When something finds its way into so many parts of life, people start to take its safety and sourcing seriously. Overuse in the environment or improper disposal has consequences, so responsible use remains key. This isn’t just theory; homeowners, teachers, and industry workers all depend on trustworthy and sustainable supplies. That means supporting processes that keep contaminants out and staying updated with research on health effects. From the flour-dusted kitchen counter to the pipes under downtown streets, choosing well-tested, reputable sources pays off.

What is the molecular weight and formula of this product?

It’s Not Just for Chemists in White Coats

Understanding the molecular weight and formula of a product might seem like something only scientists lose sleep over. Still, it shapes everyday life. Whether it’s an active ingredient in the medicine you swallow every morning or the vitamin C in your orange juice, these numbers give us a window into what exactly is entering our bodies. In industries like food, healthcare, and agriculture, nothing gets approved without producers knowing the basic building blocks of their compounds.

Real Impacts and Everyday Decisions

Take the pharmacy shelf as an example. If a label for acetaminophen reads C8H9NO2 with a molecular weight of 151.16 g/mol, that tells professionals everything from dosing to mixing it safely with other drugs. Mixing the wrong compounds because the formula got lost in translation isn’t just a paperwork headache; it’s a potential health risk. I once watched a hospital crew hustle due to an ambiguous label, and it drove home that mistakes begin where the basics get shadowy.

Quality and Safety Go Hand in Hand

No one wants surprises in their medicine, fertilizer, or packaged snacks. Regulatory bodies like the FDA and EPA don’t just ask for a product’s formula as a formality. They trace it so that every batch, whether manufactured locally or overseas, turns out as intended. If something goes wrong—a bad reaction, a failed blend, a recall—the investigation starts with the exact molecular weight and structure. Without this, tracking down the cause or pulling dangerous products off shelves gets hard and slow.

International Trade Runs on Chemical Clarity

Countries trade freight loads of chemicals, supplements, and raw materials every day. Customs and port inspectors rely on these formulas to confirm they’re not moving hazardous materials under the radar. Trade halts if inspectors face confusion over what’s inside a barrel or box. Having clear formulas and accurate weights on records smooths the process for importers and exporters, building trust with trading partners and keeping markets moving.

Innovation Starts at the Atomic Level

Every scientific breakthrough, whether it’s a more potent painkiller or a greener pesticide, starts with a team trying new combinations at the molecular level. They can’t engineer something better if they don’t have confidence in their starting point. Publishing molecular weights and formulas lets researchers around the world replicate findings, tweak recipes, and push boundaries. Patents depend on this information, too—a vague formula offers courtroom headaches, but a clear one rewards real inventors.

Transparency Keeps Us Moving Forward

People deserve to know what they’re buying, eating, spreading across crops, or giving to their kids. Labels with molecular detail might not catch your eye, but they’re a signal that the product stands up to scrutiny. Combining open access to chemical information and strong oversight ensures safety, supports discovery, and gives the public confidence in modern products. Better transparency here keeps us healthier, safer, and less likely to face unpleasant surprises.

Are there specific storage and handling precautions for this chemical?

Why Proper Handling Matters in Real Life

Most of us have wandered through a storeroom or a classroom and spotted those colorful chemical bottles gathering dust or sitting side by side. I’ve seen too many cases where someone’s curiosity or forgetfulness led to something going wrong—fumes, small fires, and ruined flooring. The trouble often starts with neglect or a lack of real-world know-how about what can or can’t stand being together on the same shelf. Storing chemicals isn’t just about neat rows. Storing chemicals wrong can wreck a business, ruin health, or worse—end lives.

Real Risks Lurking in Everyday Workspaces

Take something as basic as storing flammable liquids. If a bottle stands too close to a heat source, or if vapors mix with an open flame from someone making coffee, accidents happen fast. Statistics from the U.S. Chemical Safety Board tell us fires sparked by poor storage still send folks to the hospital every year. I’ve watched colleagues in labs shrug off safety because they believed a cap was tight enough. That’s not how prevention works. The fumes build up, the risk multiplies, and no one’s the wiser—until it’s too late.

Key Habits That Actually Keep People Safe

Here’s what I’ve learned from years spent working with chemicals, and from the guidance hammered out by groups like OSHA and the CDC:

  • Labels mean everything. Unmarked containers invite mix-ups. A simple, clear label cuts confusion and accidents overnight.
  • Separate the troublemakers. Acids don’t belong near bases. Flammables stay away from oxidizers. Cross-contamination can spark reactions that simple training can prevent.
  • Temperature has a say. Some chemicals break down or explode when left in a hot warehouse. Keeping them cool isn’t just best practice—it could save your building.
  • Airflow saves lungs. Chemicals locked up in a closet without ventilation let fumes build up, making the air something no one should breathe. Opening a vent sometimes matters more than buying special cabinets.
  • Records stop disaster before it starts. People groan about paperwork, but logs show what was moved or opened and when, letting you sweep out expired stock before it becomes a time-bomb.

Building Good Habits Without Fancy Gear

You don’t need shiny, expensive cabinets to do this right. Simple shelving made from materials that resist corrosion often makes a world of difference. Use spill trays to catch leaks before they spread. Store heavy containers close to the ground; lifting out-of-reach jugs of acid invites drops or splashes.

Ask anyone who’s spent long hours in a storeroom—they’ll tell you most accidents trace back to trying to save time or take shortcuts. Problems creep in when the space grows cluttered, or when someone stacks cleaning supplies above chemicals just to make use of a free shelf. Those so-called small decisions often play out big.

Training Everyone, Not Just the "Experts"

I’ve seen workplace culture change when people really understand what’s at stake. Training shouldn’t get dumped on the new hires and then forgotten. Regular walk-throughs, checklists, and reminders create a team that looks out for one another. The best run sites hold safety drills and revisit their plans every season. Small investments—good labels, annual reviews, quick daily inspections—add up to a safer, less stressful day at work.

Is safety data or an MSDS available for 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene?

Why Safety Data Sheets Matter

People working in chemical labs rely on safety data sheets the way climbers trust a good rope. The reason goes beyond ticking a regulatory box. MSDS documents often mean the difference between a simple mistake and a dangerous accident that sends someone to the hospital. I’ve seen interns grab compounds straight from a shipment with zero information on toxicity, and that superficial confidence evaporates after the first splash or inhalation mishap. The image of universal safety fades when you realize some new, complex molecules have barely any public hazard information available.

This Compound’s Data Desert

Take 5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene. It sounds intimidating because it is. Step into the catalogues of popular suppliers and often, you’ll see only basic handling advice: “use in well-ventilated area, avoid contact with skin and eyes.” Dig deeper, and material safety data sheets rarely show up for molecules this specialized. The data gap isn’t just an inconvenience; it can put people in real danger, particularly new researchers who trust that official documents exist per usual.

Facing Uncertainty in the Lab

I’ve worked on projects where every step starts with scouring the web for a chemical’s MSDS, hoping one appears from a manufacturer. For relatively novel compounds or ones produced for a specific research order, the paperwork just doesn’t materialize. It’s a gut-check moment—do you trust your instinct or pause experiments and consult the literature? At that point, sensible teams improvise by treating the mystery substance like any toxic, persistent, or volatile organic material. They wear full gloves, splash goggles, and lab coats, work under hoods, double-bag waste, skip inhalation-prone procedures, and record every possible accidental exposure.

The Importance of Chemical Stewardship

Standard operating procedures rarely spell out what to do with uncharacterized or barely-documented chemicals, leaving the work to researchers’ best judgment and institutional culture. Academic groups notorious for cavalier attitudes pose more risk, since accidents get swept under unofficial carpets. From experience, responsible labs treat unfamiliar chemicals with respect, isolate small quantities in experiments, and push for internal hazard reviews before any scale-up. Every time someone tries to shortcut this process because "it’s just a new building block," the odds of a severe incident jumps.

The Broader Picture: Gaps in Global Data Sharing

Most MSDS databases cover common substances or registered industrial precursors. Patented pharmaceuticals, experimental intermediates, and newly designed ligands often slip through the cracks of safety culture. This gap exposes a weakness in regulation: chemical innovation moves faster than safety rules can keep up. Without priority on hazard data, generations of bench scientists face real risk unnecessarily. In the rush to novel structures, firms and academic labs could set aside time to create MSDS reports as part of compound registration or patent submission, making them public on government or industry-supported platforms. Such habit would save plenty of anxiety and medical bills in the long run.

Moving Chemically Forward

Transparent hazard assessment shouldn’t just be a big-company problem. Skilled teams have the know-how and equipment for basic safety evaluations. Making use of this at the earliest stage—measuring volatility, respiratory hazards, or corrosivity—adds value for all future users. During my years at the bench, groups that prioritized rigorous documentation built not only a better culture, but a safer and more credible one. Safety relies not just on rules, but on scientists treating each new chemical, no matter how obscure or new, with the same seriousness as any established risk.

5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene
5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene
5-[(4-Bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene