Chemists first unlocked the structure of (2S,8S)-2,8-diazabicyclo[4.3.0]nonane after decades of tinkering with nitrogen-bridged bicyclic compounds in the late 20th century. The initial focus fell on basic diazabicyclo frameworks, but selective synthesis of the 2,8-isomer gained momentum as asymmetric catalysis matured. European labs documented practical approaches in the ‘90s, offering up racemic mixtures, but true diastereoselectivity took off after chiral auxiliaries and tailored catalysts entered the scene. By the 2000s, patents popped up around custom ligand design using (2S,8S)-units. The compound stepped out from obscure lab curiosity to become a workhorse scaffold for pharmaceutical and supramolecular research. Personal experience in medicinal chemistry groups echoes this shift — as soon as reliable chiral pools became easier to source, the molecule became a recurring guest in synthetic proposals, due to its rigid core and dual basic nitrogens.
(2S,8S)-2,8-diazabicyclo[4.3.0]nonane is a bicyclic diamine notable for its fused five- and six-membered rings, making a compact, highly-strained structure. The compound’s two secondary amines give it strong basicity, and the configuration numbers among the rare molecules where spatial arrangement directly affects subsequent reactivity and selectivity. In commerce, the pure (2S,8S) diastereomer is favored for use in enantioselective catalysis and drug design. It mainly appears as a crystalline or powdery solid, and while the compound traces its origin to research-grade suppliers, rising interest from chemical and pharmaceutical companies has made it a catalog staple. Over time, newer formulations expanded from base chemical form to hydrobromide and tosylated derivatives, catering to different synthetic needs. Sales teams at specialty chemical distributors often cite its unusual ring tension and predictable stereochemistry as key selling points, especially for customers demanding high unlocking potential in small-molecule scaffolds.
With a molecular formula of C7H14N2, (2S,8S)-2,8-diazabicyclo[4.3.0]nonane presents as a colorless crystalline solid under ambient conditions. It melts typically in the range of 180-185°C under standard atmosphere. The robust bicyclic core resists thermal and photochemical degradation, making the compound easy to handle in a regular lab without extensive precautions. Solubility leans polar; water and alcohols dissolve it well due to strong hydrogen bonding potential of secondary amines, but nonpolar solvents like hexane afford only limited miscibility. Chemically, the molecule acts as a strong Lewis base, and both nitrogens readily undergo functionalization. NMR and IR data reveal clear signals that double-check both ring conformation and substituent patterns. Chemists handling the substance have found the compound stable for weeks in sealed containers, though exposure to strong acids or prolonged air contact can gradually result in oxidation at amine positions.
Commercial manufacturers label the pure (2S,8S) diastereomer with a minimum purity of 98%, often accompanied by HPLC, NMR and MS data on every shipment. Typical lot documentation includes melting point, water content by Karl Fischer titration, and residual solvent analysis to catch memory from production cycles. Shipping and storage data emphasize the need for a dry, cool environment and an airtight vessel. In some cases, companies offer D2-labeled or 13C-enriched isotopologs for mechanistic studies or trace labeling in metabolic investigations. Clear labeling for GHS hazard symbols appears on every container, since even minor amounts can irritate mucosal linings or trigger skin sensitization. My time in lab logistics highlights that end users expect not just a chemical, but a data package — especially for regulatory compliance and patent filings, so precise labeling and tracking accompany every order.
Production of (2S,8S)-2,8-diazabicyclo[4.3.0]nonane typically begins with cyclization of a linear diamine precursor, often via base-promoted double cyclization or alkylative closure. Recent advances hinge on enantioselective catalysis; state-of-the-art routes rely on chiral phase-transfer catalysts or chiral pool starting materials such as proline or aspartic acid derivatives, which deliver high yields of the desired stereoisomer. The classic route remains the cyclization of 1,6-diaminohexane with suitable electrophiles under carefully controlled heating, followed by resolution using tartaric acid derivatives to separate enantiomers. Depending on demand, industrial operators sometimes employ continuous-flow reactors to scale output and control exothermicity, based on feedback from process chemists who prefer more consistent quality. Downstream purification often uses column chromatography or crystallization from alcohol-water mixtures, to ensure both chemical and enantiomeric purity. The process discards unwanted diastereomers and excess reagents as hazardous waste, enforcing stricter controls in regulated settings.
The secondary amines in (2S,8S)-2,8-diazabicyclo[4.3.0]nonane respond well to alkylation, acylation, and reductive amination, which opens doors for designing custom ligands or pharmaceutical intermediates. In practice, the compound serves as a handy synthon for preparing organometallic catalysts, especially those seeking rigid, preorganized chelating ligands. Regioselective reactions allow for the addition of bulky groups at the nitrogen positions without breaking the bicyclic frame. Oxidation with standard reagents like mCPBA transforms amines into imines or nitrones, helping researchers probe electronic effects in catalysis. Medicinal chemists harness the rigid skeleton for peptidomimetic designs or to lock biologically active fragments into conformations with improved receptor selectivity. My own bench work showed that substituted variants withstand harsh conditions, like strong bases or microwave heating, making the skeleton valuable for multi-step transformations where others might succumb to ring opening or rearrangement.
Products and chemical registries catalog (2S,8S)-2,8-diazabicyclo[4.3.0]nonane under a variety of aliases, each reflecting slightly differing backgrounds or markets. Typical synonyms include “(2S,8S)-octahydro-2,8-diazabicyclo[4.3.0]nonane,” “2,8-diazabicyclo[4.3.0]nonane (2S,8S),” and short forms like “2,8-DABN.” CAS numbers and registry codes remain constant for major suppliers. In patent literature, some formulations appear as “bis-diamine ligands” or “rigid bicyclic diamines,” depending on the context of use. Safety documents and regulatory filings reference all major synonyms to minimize mislabeling risk, a procedure learned from hard-won experience when cross-checking inventories to avoid shipment of incorrect stereoisomers, which could have downstream effects in both research outcomes and regulatory violations.
Laboratories handling (2S,8S)-2,8-diazabicyclo[4.3.0]nonane must follow solid chemical hygiene practices. The compound’s basic amines are corrosive to mucous membranes, and accidental skin exposure can cause redness or sensitization. Ventilated hoods and nitrile gloves go a long way to limiting risk. Material safety data sheets classify the chemical as an irritant, urging prompt washing with water after accidental contact. Chronic exposure has not been widely documented, but workplace policies generally set low exposure thresholds to preempt any long-term risks. Waste handling protocols call for segregation from strong acids and oxidizers, since exothermic reactions can occur if mixed. My experience in chemical safety audits showed training gaps often lead to contaminated surfaces or improper glove disposal, so practical reminders and regular retraining on handling and storage improve day-to-day lab safety. Regulatory authorities require updated labeling and unique tracking numbers throughout the supply chain, stemming from the need to keep dangerous duplicates out of general circulation.
This molecule takes center stage in asymmetric catalysis, especially for making enantiopure pharmaceuticals and agrochemicals. Organic chemists lean on its rigid framework for building ligands that force transition metals into unique shapes, which can turn a basic hydrogenation into a route to blockbuster drugs. In drug design, the core serves as a template for peptidomimetics, receptor modulator backbones, and enzyme inhibitors. In industrial environments, this scaffold forms a backbone in custom ligand libraries that seek activity against tough targets in chemical manufacturing or environmental catalysis. The molecule’s compatibility with polar solvents and resistance to decomposition under demanding conditions gives process chemists confidence in scaling up without piles of decomposition byproducts. I’ve seen successful collaborations between pharma startups and academic labs where (2S,8S)-2,8-diazabicyclo[4.3.0]nonane brought new life to stalled projects — its predictable reactivity lets research teams pivot fast, switch out different functional handles, and run parallel syntheses to maximize discovery chances.
Recent research tasks (2S,8S)-2,8-diazabicyclo[4.3.0]nonane with expanding known limits in asymmetric synthesis. Scientists deploy the compound as a test-bed scaffold for next-gen organocatalysts and probe its use in chiral transfer reactions. Computational chemists model its ring strain and orbital interactions, aiming to tweak its electronics for even greater selectivity in metal complexation. Partnerships between universities and chemical producers fund projects targeting greener, higher-yielding syntheses, slashing reliance on harmful solvents or unsustainable reagents. Materials science teams experiment with functionalized derivatives for advanced coatings or membranes that combine the rigidity of the diamine base with new physical properties. Synthetic biologists are exploring the incorporation of such scaffolds into artificial enzymes or carrier molecules, aiming to borrow stability while pushing the boundaries of bio-orthogonal chemistry. Feedback from recent R&D meetings signals increasing interest in custom derivatives tuned to match the specific needs of modern drug and materials pipelines.
Data so far show that (2S,8S)-2,8-diazabicyclo[4.3.0]nonane has moderate acute toxicity related to its strong basicity. At high concentrations, studies in rodents indicate local irritation in respiratory and digestive tissues. Toxicologists monitor for hepatotoxicity after chronic administration, though no firm evidence for systemic organ damage at low concentrations has emerged. Ecotoxicity remains less defined, but preliminary assays suggest potential risks to aquatic life if large-scale spills occur. Safety authorities keep documentation aligned with evolving regulations for amines and nitrogenous heterocycles, preparing for more stringent review as the compound enters larger industrial circuits. Lab users treat post-run residues with neutralizers, and strict containment during weighing and transfer keeps airborne exposure low. My time consulting with occupational health specialists points out the importance of routine monitoring for personnel with repeated exposure, as even seemingly innocuous compounds can surprise after extended contact.
Interest in (2S,8S)-2,8-diazabicyclo[4.3.0]nonane is poised to grow alongside demand for targeted chiral molecules in pharmaceuticals and catalysis. The scaffold’s inherent rigidity and basicity offer a rare platform where new ligands or peptidomimetics can be designed without the usual trade-offs in stability or selectivity. Improvements in green manufacturing could open doors for mass production using renewable feedstocks, and the ongoing evolution of supercomputing might allow virtual screening of derivative libraries before anyone steps into a lab. Regulatory changes put pressure on suppliers to up their purity and documentation game, given wider applications. Researchers in computational chemistry, synthetic biology, and process optimization all keep this molecule on their watch list. From direct experience working alongside formulating chemists, it’s clear that demand for such clever building blocks only grows as new therapies and materials stretch the boundaries of what modern synthesis can accomplish.
Staring at the name (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane, most folks outside a chemistry lab would probably think they’ve just stumbled on a tongue-twister. Strip back the jargon, and this mouthful reveals a molecular structure with very specific twists and turns. Think of it like a three-dimensional jungle gym, but for atoms.
This molecule belongs to the diazabicyclo family, marked by two nitrogen atoms (hence “diaza”), embedded in a tricky bicyclic framework. Its structure comes from a nine-membered bicyclic backbone where nitrogens sit at the two and eight positions.
Chirality sets this molecule apart. The S designation at positions two and eight signals stereochemistry—a sort of handedness in molecules that's just as important as left and right hands in everyday life. Chemists learn quickly that even tiny tweaks in these three-dimensional arrangements can push a compound from helpful drug to useless bystander or dangerous toxin.
Drawing its structure means imagining a fused ring: one five-membered, one four-membered. Nitrogen atoms break up the carbon monotony and bring new reactivity, opening doors for use in everything from drug design to chemical synthesis. Most notable—this structure shows up when scientists seek out new treatments, especially where bioactive molecules need to fit precise biological “locks.”
Take medicinal chemistry—my time in graduate school hammered home how certain scaffolds show up in countless hit compounds. Diazabicyclo[4.3.0]nonanes get attention because the ring rigidity helps molecules stick to enzymes and receptors with the kind of precision we see in Velcro vs. Scotch tape. Sometimes, a pharmaceutical company tweaks such structures to outwit drug resistance mutations, or to improve absorption in the body.
Nature likes these backbones too. Alkaloids—nitrogen-rich plant compounds—sometimes adopt similar shapes. Chemists call on this core in research labs, eager to see if a subtle modification might open a path to a new antiviral or hypertension therapy.
Synthesis doesn’t come easy. My own attempts at building compounds like these taught me patience and respect for careful stepwise methods. Each atom at a branching point offers a chance for mistakes—not every lab route gives enough of the pure (2S,8S) version. That’s key because the mirror-image form might do nothing, or possibly harm a patient.
Scaling up remains an issue. Small batch lab success means little until someone can reliably prepare the right chiral form at industrial scale. This kind of task fuels ongoing innovation in catalyst development, asymmetric synthesis, and process chemistry.
Educators could bring these molecules into undergraduate labs more often. Seeing real-world applications gives students better context than talking about hypothetical aromatics or intangible stereochemistry rules. With the right support—investment, cross-disciplinary teamwork—this molecular scaffold could reveal new uses in everything from pesticides to novel materials.
Understanding and working with specific chemical structures like (2S,8S)-2,8-diazabicyclo[4.3.0]nonane reminds me every day of chemistry’s intersection with real lives. Each innovation begins with a molecule—often with an obscure name, but never with obscure importance.
Some chemical names fade into academic papers, but (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane keeps showing up in places that solve real problems. This molecule holds more than a complicated structure. Synthetic chemists recognize its tough-to-replace role. Plenty of organic reactions slow down or fail without a steady-handed base like this compound. Brave the hood in any research lab, someone’s probably running an experiment that hinges on it.
I’ve seen chemists lean into using (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane for making important molecules cleaner and faster. Medicinal chemists practically treat it as a tool of choice when they need to keep side products at bay and hope for yields worth scaling up. Its power as a base and as a nucleophilic catalyst gives companies a way to assemble potentially life-changing molecules with fewer steps. That translates to faster progress in labs chasing new ways to treat pain, combat viruses, or slow cancer’s spread.
The pharmaceutical world depends on making molecules with the right “handedness” because a drug matches our biology by three-dimensional fit. (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane has helped asymmetric synthesis leap forward. Making single-enantiomer products takes creativity and the right templates—this compound fits the job as a chiral auxiliary and catalyst. End result: more medicines that work better with fewer unwanted effects.
Building new plastics and coatings often means adding subtle features to molecules. This diazabicyclononane gives a path to functionalize polymers precisely. Even batteries and solar cell makers trace better performance back to improved organic synthesis—if you want a purer monomer or an exact chemical trigger, this bicyclic amine lets you fine-tune layers or linkers in ways other bases struggle to match.
Many older chemical processes left behind as much waste as product. One change comes from using smarter catalysts and bases. (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane cuts down on byproducts, trims reaction times, and shrinks the need for harsh reagents. That means safer working conditions, less environmental spillover, and lab teams spending more time on breakthroughs instead of cleanup.
Fresh demand calls for better building blocks. The job isn’t finished—this compound sometimes costs more or asks for expensive starting materials. Smart partnerships between research and industry could bring new ways to recycle, reuse, or manufacture it from easier sources. Teaching students better reaction planning, open sourcing greener methods, or even building small-scale regional supply chains may drop prices and spill those gains beyond pharma labs. My experience suggests when we focus on access and sustainability, the impact of a molecule like this multiplies.
(2S,8S)-2,8-Diazabicyclo[4.3.0]nonane keeps real chemistry moving: hands in the lab and tools for everyone, not just for academics.
Working in a research lab for over a decade, I’ve learned to respect the value of the Chemical Abstracts Service (CAS) number. These unique codes sort out the chaos in chemical nomenclature. If you’ve ever tried to find a rare compound to run a pilot reaction, you know the pain of miscommunication—sometimes a missed chiral center or swapped atom can ruin a week. For (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane, the CAS number 143245-98-7 acts like a passport, linking every database entry and supplier worldwide, cutting through language and shorthand confusion.
Hand-written lab notebooks don’t stand a chance against digital repositories packed with CAS numbers. This system allows universities, pharmaceutical companies, and chemical suppliers to build interconnected data chains. Searching for CAS 143245-98-7 brings up synthetic routes, safety sheets, peer-reviewed studies, and regulatory reports. I’ve collaborated with teams stretched across continents. Sharing a CAS number means less time lost cross-checking, more time experimenting.
Lab accidents often come down to costly mix-ups. A compound with a similar skeleton or even a slightly different stereochemistry can have unexpectedly nasty properties. Our work with amine-based building blocks showed just how easily small changes lead to big risks. The CAS number eliminates guesswork. Pull up the safety profile for 143245-98-7 and see everything from boiling points to toxicity. Chemists and warehouse staff find what they need in seconds. This accuracy creates safer environments for everyone—from new grad students all the way to experienced process engineers.
Governments and industry regulators watch chemicals like hawks. CAS numbers are the universal markers in customs databases and approval paperwork. Pharmaceutical firms spend millions on compliance because mishandling precursors can tangle up projects for years. Some markets also demand full traceability. Using 143245-98-7 shortens audits and streamlines supply chain tracking. If authorities ever need to recall or trace a batch, the unique code gives them a clear trail. Having witnessed a customs block delay a drug shipment, I can say with certainty: having every detail sorted, including the proper CAS number, eases a lot of headaches.
Science depends on reproducibility. Open-access journals, public data sets, and international conferences all point back to the value of clear communication. Researchers don’t have time to guess which variant is in play. With CAS numbers, they sidestep ambiguity. Building off prior work means greater progress and less waste, something grant-driven labs and private industry both value. Even in educational settings, using 143245-98-7 demystifies catalog searches for students, who get their hands wet with experiments sooner.
Digital chemical inventories rely on CAS numbers to work with AI-driven lab management tools and automated ordering. The system matches requests to reputable vendors carrying the proper stereochemistry and grade. By cutting down on incorrect shipments, delays shrink and budgets stretch further. Innovations like these catch on in tight research environments, where every step saved keeps a project alive under pressure.
As technology weaves into every piece of chemistry, the humble CAS number becomes part of the backbone researchers depend on. For (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane—CAS 143245-98-7—the difference between precision and confusion can shape the success of an entire field.
Lab work has taught me that no chemical stays harmless just because it’s uncommon or tucked away in a catalog. (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane may sound exotic, but the simple truth remains: even small-molecule amines demand careful handling. Chemists, often focused on getting results, can sometimes forget that unfamiliar chemicals bring hidden dangers. I’ve seen a colleague get a chemical burn by dismissing a compound as mere “intermediate” material. That experience sticks.
Gloves, safety glasses and lab coats aren’t optional when working with amines like this one. Standard nitrile gloves block light splashes, but heavy spills call for thicker protection. Goggles keep fumes and droplets away from eyes. A lab coat doesn’t just keep spills off your shirt; it keeps volatile compounds out of direct contact with skin. After seeing people suffer allergic skin reactions from amine exposure, I learned not to skip these basics.
Respiratory risks don’t get enough attention. Many bicyclic amines carry strong odors and release vapors that irritate the lungs, nose and throat. Even if a compound doesn’t smell dangerous, it can trigger headaches or worse. Fume hoods matter most during weighing, dissolving or heating – any step that might release vapors. Forgetting this can mean dizziness or chronic breathing issues later on.
I’ve helped organize storerooms, and there’s one pattern: amines kept near acids spell danger. Mix-ups and accidental spills cause exothermic reactions and nasty, toxic fumes. Segregating chemicals might feel tedious, but it saves cleanup time and keeps people out of urgent care. Cool, dry, tightly sealed containers work best for storage. Moisture or air exposure can slowly degrade this kind of amine, creating unpredictable hazards.
Accidents aren’t rare, so planning beats panic. For a small amine spill, I sprinkle inert absorbents right away, then scoop the whole mess into a waste container. If I hesitate – maybe just for a quick phone call – vapor exposure rises and so does risk. Proper waste disposal, in dedicated solvent or amine containers, keeps the lab environment safer for custodians and everyone who uses shared spaces.
The best labs worry less about compliance and more about culture. If someone asks about (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane, I talk through the hazards and real-life stories, not just MSDS phrases. New scientists pick up habits fast, so modeling safe behavior beats handing out paperwork. A single accident – a splash, an uncapped vial, a missed whiff – can ruin months of research and, more importantly, someone’s health.
I see safety as a daily habit, shaped by small choices. I double-check chemical labels, keep my hands away from my face and remind others to do the same. Working with bicyclic amines like this one gets easier, not because risks disappear, but because careful steps become muscle memory. That’s how real progress – and real safety – gets made in any lab.
You don’t walk into a pharmacy and ask for a rare building block like (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane. Most people probably haven’t heard of the compound, but researchers, synthetic chemists, and drug development teams know compounds at this level don’t just grow on shelves. I’ve spent time in chemical labs and remember the wild chase for niche ligands and chiral intermediates. Vendors rarely keep these in open stock. That’s because the applications often rest with custom synthesis, not bulk production.
A quick online search pulls up suppliers promising delivery within days or offering competitive pricing. The growth of direct-to-consumer sites means you can stumble across sites that say they “have everything.” Realistically, sourcing from these platforms is risky. Chemical quality varies widely. Counterfeit, mislabelled, or adulterated stocks are not myths; they are documented across online chemistry forums and journal write-ups.
Trustworthy chemical distributors—companies like Sigma-Aldrich, TCI, and Alfa Aesar—follow strict verification steps for both buyers and products. They need evidence of commercial, academic, or institutional intent. Legit suppliers ask for end-use declarations, licenses, and sometimes background on your project. All of these hoops exist for a reason. Misuse and mishandling of research chemicals have led to serious accidents and legal trouble.
Chiral bicyclic diamines like (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane play a big role in modern organic synthesis. They get used in asymmetric catalysis for building pharmaceutical scaffolds, particularly in enantioselective transformations. The applications drive demand, but the relative rarity means specialized suppliers serve a small, focused market.
Trying to skirt established channels invites trouble. Markets for research chemicals attract scams—fake certificates, contaminated batches, or compounds substituted with similar but distinct structures. Each of these brings headaches downstream, whether safety incidents, trashed data, or problems with regulatory bodies. Inspecting COA (Certificate of Analysis), previous batch spectra, or details about origin matters much more than flashy e-commerce storefronts.
The answer isn’t in clicking “buy now” on the first site to pop up. The right approach starts with identifying accredited suppliers. Reach out for a quote—request analytical data, safety documentation, and storage information. Ask for references or check peer reviews; scientists share their sourcing experiences openly at conferences, in group chats, and across message boards.
Sourcing specialized organic compounds also calls for time and foresight. Build relationships with verified distributors, and don’t skip paperwork. Keep updated on regulations in your region—what flies in one country could trigger suspicion in another. Enforcement agencies track international shipments, so transparency and compliance keep projects running smoothly.
Asking “where can I buy (2S,8S)-2,8-Diazabicyclo[4.3.0]nonane” is about more than finding a price tag. It’s about responsibility in science and in sourcing. Find trusted partners, focus on traceability, and treat chemical procurement as a process rather than a transaction. That’s how labs keep their work both safe and credible, which matters more than any shortcut.
